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Examining the numerous factors influencing hematopoietic cell transplantation (HCT) outcomes
Many factors influence HCT outcomes, such as the selected graft source, type of infused cell subsets, cell doses, and the protocols used for conditioning, immune suppression, and treatment of adverse events. Recent pharmacokinetic studies show that compounds used in the conditioning regimen (e.g. busulphan, fludarabine, anti-thymocyte globulin) should use patient-specific dosing to achieve optimal exposure in every individual patient.
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Due to a multitude of variables, harmonization between HCT centers is still difficult to achieve. Dr. Boelens shares his investigations to improve immune recovery after HCT to limit both relapse and non-relapse mortality (death due to viral reactivations and graft-versus-host disease).
Recorded Oct 23, 2018
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Dr. Boelens is a pediatric hematologic oncologist specializing in bone marrow and cord blood transplantation to treat blood diseases in children and young adults. Dr. Boelens has particular expertise caring for people with rare diseases, such as lysosomal storage disorders like Hurler’s disease and leukodystrophies like metachromatic leukodystrophy, adrenoleukodystrophy, and Krabbe disease.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly.
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People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly. So they're able to anticipate — and exponentially increase — the impact of care.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly. So they're able to anticipate — and exponentially increase — the impact of care.