Webcast: Combatting GVHD with UCB-derived regulatory T cells
Examine the latest research with John Wagner, M.D.
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Examine the latest research with John Wagner, M.D.
Save the Cord Foundation and WellSky are proud to present pioneering researcher John Wagner, MD, as he shares some of his latest work involving potential treatment of autoimmunity and graft-versus-host disease (GVHD).
Infection and relapse are the principal obstacles to successful use of allogeneic hematopoietic stem cell transplantation. Prolonged immunodeficiency is a major cause of infection and relapse, particularly in those with high-risk disease, older age, use of in vivo and ex vivo T cell depletion, HLA mismatch, and after the development of acute and chronic GVHD.
Trials have demonstrated that the infusion of umbilical cord blood (UCB) derived regulatory T cells (Tregs) could effectively prevent GVHD. Join Dr. Wagner as he also shares how thymic progenitor cells (Pro-Ts) can repair damaged immune systems, and how UCB can reliably provide large numbers of Pro-Ts suitable for clinical use.
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Recorded Oct 23, 2018
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Dr. Wagner's research is focused on the development of novel cell therapies for treatment of life threatening diseases. Examples include the development of regulatory T cells that could be used in the treatment of autoimmunity, organ graft rejection as well as graft-versus-host disease, thymic progenitors to repair damaged immune systems, cardiac myoblasts to reverse heart failure, skeletal myoblasts to repair or replace dystrophic muscle fibers in muscular dystrophy, and expansion of the blood-forming stem cell to speed blood and marrow recovery after high doses of chemotherapy and radiation. Dr. Wagner is best known for his pioneering work on the use of placental/cord blood as a source of stem cells for transplantation – a procedure that has now been performed in more than 50,000 patients worldwide.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly.
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People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly. So they're able to anticipate — and exponentially increase — the impact of care.
People who choose a life of caring — and the organizations and communities they serve — deserve a special kind of support. So we help them to care smarter. Liberating them to focus on the people they serve. Providing solutions that make work flow, integrate insights, and update effortlessly. So they're able to anticipate — and exponentially increase — the impact of care.